https://herbertlab.com/publications/2026-02-16T08:41:23+00:00weekly0.6https://herbertlab.com/research/https://herbertlab.com/wp-content/uploads/2025/05/summary-figure.pngSummary Figure<strong>(Fig. 3) Interphase cell shape defines the mode, symmetry and outcome of mitosis:</strong> As cells elongate, they switch to a newly defined isomorphic mode of division. In isomorphic divisions, cells uncharacteristically retain pre-mitotic asymmetries in morphology and fate determinant positioning throughout mitosis. Consequently, isomorphic division fundamentally couples dynamic changes in interphase shape to the induction of asymmetric cell divisions (adapted from Lovegrove et. al., 2025. <em>Science.</em>).https://herbertlab.com/wp-content/uploads/2025/05/figure-6.pngFigure 6<strong>(Fig. 5) TRAK2 mRNA localisation spatially modulates TRAK2-MIRO1 interactions:</strong> (a) Proximity ligation assay (PLA) reveals that loss of a 29bp 3’UTR motif that underpins the cell-size-scaling of TRAK2 mRNA localisation disrupts the spatial distribution of TRAK2-MIRO1 interactions. (b) Consequently, in the absence of TRAK2 mRNA localisation, mitochondria accumulate at distal sites in a cell-size-dependent manner (adapted from Bradbury et. al., 2025. <em>bioRxiv.</em>).https://herbertlab.com/wp-content/uploads/2025/05/figure-1.pngFigure 1<strong>( (Fig. 2) A switch to isomorphic division breaks the symmetry of daughter cell size: </strong> (a) Schematic of classical cell division. (b) Still images of a human EC in 2D culture undergoing mitotic rounding in division. (c) Still images of a zebrafish ‘tip’ endothelial cell undergoing isomorphic division to generate daughter of differential size (adapted from Lovegrove et. al., 2025. <em>Science.</em>). https://herbertlab.com/wp-content/uploads/2019/09/tip-cell-genes.pngtip cell geneshttps://herbertlab.com/wp-content/uploads/2019/09/mrna.pngmRNAhttps://herbertlab.com/wp-content/uploads/2019/09/untitled-4-1.pngUntitled-4https://herbertlab.com/wp-content/uploads/2019/09/tip-stalk.pngtip stalkEndothelial tip and stalk cells display distinct behaviour and function: Time-lapse images of mosaic individual lyn-mCherry expressing tip or stalk cells and quantification of the dorsal movement of cell nuclei and the top, bottom and centre of migrating cells.2025-05-06T05:30:07+00:00weekly0.6https://herbertlab.com/people/https://herbertlab.com/wp-content/uploads/2025/05/mujtaba-e1746481102737.jpgMujtabaMujtaba Ansarihttps://herbertlab.com/wp-content/uploads/2025/05/wednesday.jpgWednesdayWednesday Tarhan-Kinghttps://herbertlab.com/wp-content/uploads/2025/05/georgia-e1746479947354.jpgGeorgiahttps://herbertlab.com/wp-content/uploads/2025/05/brendan-e1746479201618.jpgBrendanhttps://herbertlab.com/wp-content/uploads/2021/02/georgia.jpgGeorgia HulmesGeorgia Hulmeshttps://herbertlab.com/wp-content/uploads/2019/09/screenshot_20190918-234945.pngScreenshot_20190918-234945George Charalamboushttps://herbertlab.com/wp-content/uploads/2019/09/photo-2.jpgphotoGeorge Charalamboushttps://herbertlab.com/wp-content/uploads/2019/09/josh.jpgjoshJoshua Bradburyhttps://herbertlab.com/wp-content/uploads/2019/09/sabrina-and-cerise.jpgSabrina and CeriseSabrina Ghadaouiahttps://herbertlab.com/wp-content/uploads/2019/09/raphael.jpgRaphaelRaphael Thuret2025-05-05T21:40:54+00:00weekly0.6https://herbertlab.com/lab-events/https://herbertlab.com/wp-content/uploads/2025/05/lab-retreat-2021.jpeglab retreat 2021https://herbertlab.com/wp-content/uploads/2025/05/lab-retreat-2022-feb.jpegLab Retreat 2022 Febhttps://herbertlab.com/wp-content/uploads/2025/05/lab-retreat-2022.jpegLab retreat 2022https://herbertlab.com/wp-content/uploads/2025/05/axe-throwing-2023.jpegAxe throwing 2023https://herbertlab.com/wp-content/uploads/2025/05/xmas-2023.jpegXmas 2023https://herbertlab.com/wp-content/uploads/2025/05/lab-retreat-2024.jpegLab retreat 2024https://herbertlab.com/wp-content/uploads/2025/05/lab-retreat-oct-2024.jpeglab retreat Oct 2024https://herbertlab.com/wp-content/uploads/2025/05/xmas-dinner-2024.jpegXmas dinner 2024https://herbertlab.com/wp-content/uploads/2020/02/img_4323.jpegIMG_4323https://herbertlab.com/wp-content/uploads/2020/02/img_4339.jpegIMG_43392025-05-05T20:44:29+00:00weekly0.6https://herbertlab.com/overview-3/2025-05-05T19:58:40+00:00weekly0.6https://herbertlab.com/contact/2019-09-16T12:26:27+00:00weekly0.6https://herbertlab.comdaily1.02026-02-16T08:41:23+00:00