Publications

Lovegrove HE*, Hulmes GE*, Ghadaouia S, Revell C, Giralt-Pujol M, Alhashem Z, Pena A, Nogare DD, Appleton E, Costa G, Mort RL, Ballestrem C, Jones GW, Manning CS, Chitnis AB, Franco CA, Linker C, Bentley K, Herbert SP. Interphase cell morphology defines the mode, symmetry, and outcome of mitosis. (2025) Science; May;388(6746):eadu9628. doi: 10.1126/science.adu9628. (free access reprint link: https://www.science.org/stoken/author-tokens/ST-2608/full [science.org])

Bradbury JJ, Hulmes GE, Viswanathan R, Costa G, Lovegrove HE, Herbert SP. mRNA trafficking directs cell-size-scaling of mitochondria distribution and function. (2025) Nat Commun. 16, 7029. https://doi.org/10.1038/s41467-025-61940-6.

Capey B, Herbert SP. Establishment & maintenance of collective cell migration in angiogenesis: Lessons from zebrafish. (2025) Semin Cell Dev Biol. Jul 15:173:103627. doi: 10.1016/j.semcdb.2025.103627.

Lovegrove HE, Herbert SP. Time-Lapse Imaging of Asymmetric Spindle Positioning During Endothelial Tip Cell Division in Angiogenesis In Vivo. (2025) Methods Mol Biol. 2872:269-286. doi: 10.1007/978-1-0716-4224-5_19.

Ristori T, Thuret R, Hooker E, Quicke P, Lanthier K, Ntumba K, Aspalter IM, Uroz M, Herbert SP, Chen CS, Larrivée B, Bentley K. Bmp9 regulates Notch signaling and the temporal dynamics of angiogenesis via Lunatic Fringe. (2023) bioRxiv. Sep 25:2023.09.25.557123. doi: 10.1101/2023.09.25.557123. 

Bradbury JJ, Lovegrove HE, Giralt-Pujol M, Herbert SP. Analysis of mRNA Subcellular Distribution in Collective Cell Migration. (2023) Methods Mol Biol; 2608:389-407. doi: 10.1007/978-1-0716-2887-4_22.

Zakirov B, Charalambous G, Thuret R, Aspalter IM, Van-Vuuren K, Mead T, Harrington K, Regan ER, Herbert SP, Bentley K. Active perception during angiogenesis: Filopodia speed up Notch selection of tip cells in silico and in vivo. (2021) Philosophical Transactions of The Royal Society B; Mar 29;376(1821):20190753. doi: 10.1098/rstb.2019.0753.

Costa G, Bradbury J, Tarannum N, Herbert SP. RAB13 mRNA compartmentalisation spatially orients tissue morphogenesis. (2020); The EMBO Journal; 39(21). e106003. doi: 10.15252/embj.2020106003

Herbert SP, Costa G. Sending messages in moving cells: mRNA localization and the regulation of cell migration. (2019); Essays in Biochemistry; Jul 19. pii: EBC20190009, doi: 10.1042/EBC20190009

Page DJ, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert SP. Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. (2019); Cell Reports; 27, 3139-3151 e3135, doi:10.1016/j.celrep.2019.05.052. PMCID: PMC6581738

Costa G, Lovegrove HE, Herbert SP. Endothelial cells divide unequally to sprout fairly. (2017); Cell Cycle; Apr 3;16(7):595-596. doi: 10.1080/15384101.2017.1294942. PMCID: PMC5397259

Costa G, Harrington KI, Lovegrove HE, Page DJ, Chakravartula S, Bentley K, Herbert SP. Asymmetric division coordinates collective cell migration in angiogenesis. (2016); Nature Cell Biology; 18(12):1292-1301. doi: 10.1038/ncb3443. PMCID: PMC5548250

Sacilotto N, Chouliaras K, Nikitenko L, Wei Lu Y, fritzsche M, Wallace M, Nornes S, García-Moreno F, Payne S, Bridges E, Liu K, Biggs D, Ratnayaka I, Herbert SP, Molnár Z, Harris A, Davies B, Bond G, Bou-Gharios G, Schwarz J, De Val S. MEF2 transcription factors are key regulators of sprouting angiogenesis. (2016) Genes and Development; 30(20) 2297-2309. doi: 10.1101/gad.290619.116. PMCID: PMC5110996

Herbert SP*, Cheung JYM, Stainier DY*. Determination of Endothelial Stalk versus Tip Cell Potential during Angiogenesis by H2.0-like Homeobox-1. (2012) Current Biology; 22(19), 1789-94. doi: 10.1016/j.cub.2012.07.037. PMCID: PMC3471071 (* co-corresponding authors)

Herbert SP, Stainier DY. Molecular control of endothelial cell behaviour during blood vessel morphogenesis. (2011) Nature Reviews Molecular Cell Biology. Aug 23;12(9):551-64. doi: 10.1038/nrm3176. PMCID: PMC3319719

Bruns AF*, Herbert SP*, Odell AF*, Jopling HM, Hooper NM, Zachary IC, Walker JH, Ponnambalam S. Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis. (2010) Traffic. 11(1), 161-74. doi: 10.1111/j.1600-0854.2009.01001.x. (* equal contribution)

Herbert SP, Huisken J, Kim TN, Feldman ME, Houseman BT, Wang RA, Shokat KM, Stainier DY. Arterial-venous segregation by selective cell sprouting: an alternative mode of blood vessel formation. (2009) Science. Oct 9;326(5950):294-8. doi: 10.1126/science.1178577. PMCID: PMC2865998

Herbert SP, Odell AF, Ponnambalam S, Walker JH. Activation of cytosolic phospholipase A2-a as a novel mechanism regulating endothelial cell cycle progression and angiogenesis. (2009) J Biol Chem. Feb 27;284(9):5784-96. doi: 10.1074/jbc.M807282200. PMCID: PMC2645829.

Hastings AD, Herbert SP, Gawler D, Walker JH. Association with actin mediates the EGTA-resistant binding of cytosolic phospholipase A2-alpha to the plasma membrane of activated platelets. (2009) Cell Biol Int. Jan;33(1):83-91. doi: 10.1016/j.cellbi.2008.09.010.

Herbert SP, Odell AF, Ponnambalam S, Walker JH. The confluence-dependent interaction of cytosolic phospholipase A2-alpha with annexin A1 regulates endothelial cell prostaglandin E2 generation. (2007) J Biol Chem. Nov 23;282(47):34468-78. doi: 10.1074/jbc.M701541200.

Herbert SP, Walker JH. Group VIA calcium-independent phospholipase A2 mediates endothelial cell S phase progression. (2006) J Biol Chem. Nov 24;281(47):35709-16. doi: 10.1074/jbc.M600699200.

Herbert SP, Ponnambalam S, Walker JH. Cytosolic phospholipase A2-alpha mediates endothelial cell proliferation and is inactivated by association with the Golgi apparatus. (2005) Mol Biol Cell. Aug;16(8):3800-9. doi: 10.1091/mbc.e05-02-0164. PMCID: PMC1182317

Grewal S, Herbert SP, Ponnambalam S, Walker JH. Cytosolic phospholipase A2-alpha and cyclooxygenase-2 localize to intracellular membranes of EA.hy.926 endothelial cells that are distinct from the endoplasmic reticulum and the Golgi apparatus. (2005) FEBS J. Mar;272(5):1278-90. doi: 10.1111/j.1742-4658.2005.04565.x.

Howell GJ, Herbert SP, Smith JM, Mittar S, Ewan LC, Mohammed M, Hunter AR, Simpson N, Turner AJ, Zachary I, Walker JH, Ponnambalam S. Endothelial cell confluence regulates Weibel-Palade body formation. (2004) Mol Membr Biol. Nov-Dec;21(6):413-21. doi: 10.1080/09687860400011571.